3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a
potent psychedelic drug inducing euphoria and hyper-sociability
in humans, as well as hyperactivity and anxiety in rodents. Adult
zebrafish (Danio rerio) have become a widely used species in
Buy 120 mg MDMA Pills Online
MDMA 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a potent psychedelic drug inducing euphoria and hyper-
sociability in humans, as well as hyperactivity and anxiety in rodents. Buy 120 mg MDMA Pills OnlineAdult zebrafish (Danio rerio)
have become a widely used species in neurobehavioral research. Here, we explore the effects of a wide range (0.25-120 mg/L)
of acute MDMA doses on zebrafish behavior in the novel tank test. While MDMA was inactive at lower doses (0.25-10 mg/L),
higher doses reduced bottom swimming and immobility (40-120 mg/L) and impaired intra-session habituation (10-120 mg/L).
MDMA also elevated brain c-fos expression, collectively confirming the utility of zebrafish models for screening of hallucinogenic
compounds.Buy 120 mg MDMA Pills Online
3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a popular recreational drug that modulates brain monoamines by
inhibiting their reuptake (White et al., 1996; Kalant, 2001; de la Torre et al., 2004; Nagai et al., 2007; Doly et al., 2009) and
degradation (Leonardi & Azmitia, 1994). The serotonergic system appears to be the primary target of MDMA action, although
dopamine also plays an important role (Benturquia et al., 2008; NIDA, 2010; Stove et al., 2010).
Typical clinical effects of MDMA include euphoria, elation and sociability (Parrott, 2007; Bedi et al., 2009; Stove et al., 2010).
MDMA can evoke adverse effects, including anxiety, depression, psychoses and cognitive deficits (Hall & Henry, 2006; Control,
2009; NIDA, 2010).
The behavioral effects of acute MDMA have been extensively investigated in various animal models. In rodents, MDMA induces
robust hyperlocomotion (Benturquia et al., 2008; Colussi-Mas & Schenk, 2008; Stove et al., 2010) and anxiety (Lin et al., 1999; Ho
et al., 2004).Buy 120 mg MDMA Pills Online
Previous research has utilized the zebrafish as a model sensitive to various pharmacological manipulations, including
hallucinogens lysergic acid diethylamide (LSD) and salvinorin A (Braida et al., 2007; Grossman et al., 2010). Since MDMA has not
yet been tested in zebrafish, we examined its behavioral effects on this species. Finally, published rodent data shows that
psychedelic agents (e.g., LSD and MDMA), elevate the expression of c-fos, serving as a marker of neuronal activation that
correlates with behavioral alterations (Salzmann et al., 2003; Benturquia et al., 2008; Reissig et al., 2008). Based on earlier
studies validating brain c-fos analyses in zebrafish (Baraban et al., 2005; Wong et al., 2010b), we also examined the effects of
MDMA on c-fos expression. MDMA was first made in 1912.It was used to improve psychotherapy beginning in the 1970s and
became popular as a street drug in the 1980s.MDMA is commonly associated with dance parties, raves, and electronic dance
music.!t is often sold mixed with other substances such as ephedrine, amphetamine, and methamphetamine.In 2016, about 21
million people between the ages of 15 and 64 used ecstasy (0.3% of the world population). This was broadly similar to the
percentage of people who use cocaine or amphetamines, but fewer than for cannabis or opioids.in the United States, as of 2017,
about 7% of people have used MDMA at some point in their life and 0.9% have used in the last year.Buy 120 mg MDMA Pills
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